The sustained low prices of oil and gas (O&G) and the structural changes that occur in the O&G industry have resulted in reconsidering of a wide range of practices at a sector of outmost importance for Cyprus. Although Drill Cuttings (DC) constitute one of the most important residues of the sector, their disposal causes environmental burden and their treatment contributes significant cost due to application of energy intensive thermal methods. OzoneBioPro is a national project aspiring to develop a sophisticated hybrid ozone oxidation-bioremediation system aimed to treat DC at pilot-scale and to produce added-value compost as well as a microbial consortium enhancing the treatment capacity of DC bioremediation processes. A pilot-plant will be designed and constructed based on the wide expertise of IESC in developing full-scale applications, while the operation of ozonation and bioremediation will be tested to optimize treatment efficiency. Moreover, Next Generation Sequencing and qPCR will be applied by CUT to quantitatively detect the expression of important genes involved in the process and to determine the composition of the microbial community formed depending on operational parameters. Through the project an alternative and sustainable strategic waste valorization plan will be constructed, while the company aims in moving the technology to process scale for the management of DC in Cyprus and internationally.